Common brands: Ativan, Tavor
Lorazepam HF 2.5 mg
Lorazepam is one of the most important active ingredients in the benzodiazepine class, a group of sedatives. It is mainly used to treat anxiety disorders, but also has a sedative, anticonvulsant and muscle-relaxant effect. Because of its broad spectrum of action and many years of experience in use, the active ingredient is widely used.
How lorazepam works:
Lorazepam is a drug from the benzodiazepine group and, as such, has anxiety-relieving (anxiolytic), sedative (tranquilizing), muscle-relaxing (muscle-relaxing), and anticonvulsant (anticonvulsant) effects.
Like all benzodiazepines, lorazepam wikr directly at the junctions between nerve cells in the brain. At these so-called synapses, the nerve cells communicate with each other via messenger substances (neurotransmitters).
Some messengers trigger excitation (in the form of an electrical potential) in the target cell, while others inhibit the target cell’s ability to excite. The latter are also called inhibitory neurotransmitters, and the most common and important neurotransmitter in this class is GABA (gamma-aminobutyric acid).
Lorazepam binds to a subtype of the GABA binding site (GABA-A receptor) and increases the opening probability in the presence of GABA. In this way, the inhibitory effect of GABA is enhanced.
The side effects of lorazepam usually result directly from the desired depressant effect:
More than one in ten patients experience fatigue, drowsiness, and dizziness. More than one in a hundred patients experience drowsiness, muscle weakness, confusion, depression, and dizziness.
Children, the elderly and people with brain diseases may react paradoxically to the drug, i.e. with agitation, restlessness, sleep disturbances or increased anxiety.